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researchfocusREVIEWSMicrodispensingtechnologiesindrugdiscoveryDonRoseBecauseoftheadventofmanagedcare,thepharma-targets.Asaresultoftheincreasednumbersoftargetsandcompounds,drugscreeninghasbeguntoincorporateceuticalindustryisenteringanewera,characterizedautomationthatwaspreviouslyfoundinanalyticalchem-byincreasedcompetitionandpricingpressures.Asaistrylaboratories,oronmanufacturingfloors,tocreateresult,drugdiscoverywithinpharmaceuticalcompa-high-throughputscreening(HTS).Onecommonthemeamongmanyofthesetechnologi-niesisrapidlyembracingnewparadigmstohelpbringcaladvanceshasbeenareductioninthescaleofthesemorenoveldrugstothemarketasrapidlyaspossible.techniques.Whetherachemicalsynthesis,biochemicalOneparadigmcurrentlybeingpursuedistheminia-assayorpolymerasechainreaction(PCR),thescaleissteadilybeingreducedinanefforttocutreagentcostsandturizationoftheprocessesinvolvedintheexploratoryincreasesamplethroughput.Thisreductioninscalehasphaseofdrugdiscovery.Thisreductioninscalehascreatedaneedformicroscaleliquidhandling–thedis-pensingandtransferofsubmicrolitervolumes.Thisarticleledtothedevelopmentofnewdispensingtechnol-reviewstheemergingtechnologiesthatareusefulforogies.Thisreviewexaminesseveralmicrodispensingmicrodispensingastheyapplytodrugdiscovery.Itshouldtechnologiesfordrugdiscovery.benotedthat,becauseoftherecentemergenceofthisareaandthefactthatthefieldisdevelopingprimarilyout-sideacademicareas,thisreviewcontainslittlepublishedliteratureandisbasedprimarilyontradejournaldescrip-tions,productliterature,conferenceproceedingsandcus-tomerapplications.rugdiscoveryisenteringaneweraandpharma-ceuticalcompaniesareexperiencingincreasingMicrodispensingtechnologiesmarketpressurestodelivernoveldrugsinaIndrugdiscovery,mostautomatedliquidhandlingisDtimelymannerthataddressunmetmedicalaccomplishedusingeithersyringepump-basedpipettorsneeds.Atthesametime,newtechnologiesarebeingfortransferringfluid,orperistalticpumpsforreagentfill-developedthatwillgreatlyacceleratethe
